Hooke Kits™ for induction of CIA
For induction of collagen-induced arthritis (CIA) in mice
All reagents are supplied in pre-filled syringes, ready to use.
- Ensure reliable and consistent CIA induction
Each batch is extensively tested and individually adjusted to ensure consistent disease induction.
- Eliminate tedious preparation of emulsions
Properly prepared emulsions are critical for reliable induction of CIA. Our emulsions are carefully made and pre-filled into syringes, ready to use, to reduce time needed to set up experiments.
- Save time and mice in testing individual reagents
Batch-to-batch reagent variations can cause dramatic changes in severity of induced autoimmune disease. The consistent potency of pre-characterized Hooke Kits™ eliminates time-consuming testing.
- Reduce your mouse facility’s exposure to pathogen contamination
Pre-filled syringes are prepared under aseptic conditions and delivered in sterilized plastic bags for easy disinfection before introduction into your mouse facility.
Collagen-induced arthritis (CIA) is one of the most commonly used animal models of human rheumatoid arthritis (RA).
Joint inflammation, which develops in animals with CIA, strongly resembles inflammation observed in patients with RA. Blocking tumor necrosis factor (TNF) is efficacious in treatment of CIA, just as it is a highly efficacious therapy in treatment of RA patients.
CIA is mediated by both T-cells and antibodies (B-cells). Macrophages are believed to play an important role in mediating tissue damage during disease development.
Type II Collagen Emulsions for CIA induction in DBA/1 mice
CIA is induced by immunization with collagen/CFA emulsion, followed 3 weeks later by collagen/IFA emulsion. See recommended protocol and product details.
While both bovine type II and chicken type II collagen are used for CIA induction, we observe more uniform and more severe CIA with chicken type II collagen.
| Cat # | Hooke Kit™ | Strain | Age | Description | Size | Price (first kit) |
Price (each add'l kit) |
|---|---|---|---|---|---|---|---|
| EK-0210 | Chicken Collagen/CFA Emulsion | DBA/1 | 7–10 weeks | Type II collagen/CFA emulsion in pre-filled syringe |
20 mice | $ 334 | $ 268 |
| EK-0211 | Chicken Collagen/IFA Emulsion | DBA/1 | 7–10 weeks | Type II collagen/IFA emulsion in pre-filled syringe |
20 mice | $ 313 | $ 251 |
| EK-0220 | Bovine Collagen/CFA Emulsion | DBA/1 | 7–10 weeks | Type II collagen/CFA emulsion in pre-filled syringe |
20 mice | $ 334 | $ 268 |
| EK-0221 | Bovine Collagen/IFA Emulsion | DBA/1 | 7–10 weeks | Type II collagen/IFA emulsion in pre-filled syringe |
20 mice | $ 313 | $ 251 |
These kits can be customized for a small additional charge. Contact us at or with your requirements.
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