Careers
Skip the commute to Cambridge - improve your quality of life!
Hooke is a privately owned, founder-led preclinical CRO focused on rodent in vivo immunology. We're proud to have never had a layoff since our founding in 2007.
We're in Lawrence MA, close to I-93 and I-495, next to Andover. In Q1 2027 we're moving 5 minutes north to a larger facility in Salem NH (which has no state income tax).
Hooke offers full-service preclinical CRO services in rodent models of autoimmune diseases, including multiple sclerosis (EAE), rheumatoid arthritis (CIA), inflammatory bowel disease (colitis models), and systemic lupus. We emphasize scientific rigor, thoughtful study design, and long-term customer relationships.
We also offer kit products, histology, immunohistochemistry, multiplex immunofluorescence, RNA-seq, scRNA-seq, bioinformatics, cytokine analysis, and flow cytometry services.
Within our specialty, we believe we're the most active and respected CRO in the world. Our customers include leading international pharmas - including 8 of the top 10 and 15 of the top 20 - as well as venture-funded biotechs, universities, and small startups.
Customers come to Hooke not just for model execution but for expertise and advice - we help clients design studies and identify the mode of action of their compounds. Our lab is a fast-paced scientific environment with a focus on quality, efficiency, and a minimum of red tape.
For all positions, Hooke offers:
- Health insurance
- Company contributions to HSA accounts
- Paid vacation
- 401(k) plan
Current open positions (click for details on each):
PhD Immunologist - Flow Cytometry & In Vivo Models
Experienced Research Immunologists/In Vivo Pharmacologists
Entry-level Scientists
For all positions, you must be legally authorized to work in the US. Applications are accepted by email only (see details in each listing).
PhD Immunologist - Flow Cytometry & In Vivo Models
We are seeking an early-career PhD immunologist with strong expertise in flow cytometry. You will be working with rodent models of immune-mediated diseases.
What you will do:
- Design, optimize, and run multi-color flow cytometry panels (including high-parameter/spectral systems)
- Operate spectral and polychromatic flow cytometers
- Analyze and interpret flow cytometric results from rodent and human tissues
- Integrate flow cytometry into in vivo study design and readouts
- Contribute to interpretation of results from models of autoimmune diseases (EAE, lupus, arthritis, etc.)
- Support preparation of clear, high-quality reports
- Help refine internal assays, panels, and scientific approaches
Requirements:
- PhD in immunology (recent graduate to early-career)
- Strong hands-on experience with flow cytometry
- Multi-color panel design
- Compensation/unmixing
- Data analysis (FlowJo or similar)
- Experience with high-parameter flow (≥12 colors); spectral cytometry is a strong plus
- Interest or experience in working hands-on with rodent models of immune-mediated diseases
- Excellent understanding of immune cell phenotyping
- Careful, detail-oriented approach to experimental design, study execution, and data analysis
Nice to have:
- Experience with genomics and gene-editing techniques such as CRISPR-Cas9
To apply:
- Email to (no calls, please)
- Attach your resume or CV in PDF format
- Include contact information for three references
- Put "IMMUNO_FLOW - [initials] [family name]" in the subject line
Experienced Research Immunologists/In Vivo Pharmacologists
We have multiple openings for research scientists with 2 to 10 years of experience in immunology or in vivo pharmacology. We're looking for scientists both to work in the lab, and to work with our CRO customers via email and telephone.
The ideal candidates will be:
- Proficient at handling and dosing lab mice and rats
- Experienced running autoimmunity models in rodents (EAE, CIA, colitis, SLE)
- Experienced with other laboratory technologies such as tissue culture, ELISA, and flow cytometry
- Responsible and detail-oriented
- A flexible, self-motivated team player
- Ready to learn and work hard at doing good science for our customers
Pay is very competitive, based on experience. Hooke offers health insurance, 401(k), company contributions to HSAs, and paid vacation.
To apply:
- Email to (no calls, please)
- Attach your resume or CV in PDF format
- Include contact information for three references
- Put "SCIENTIST - [initials] [family name]" in the subject line
Entry-Level Scientists
We have multiple openings for entry-level scientists in immunology and in vivo pharmacology. No previous research experience is needed for these positions, but you must be detail-oriented and willing to learn.
You must be flexible re work hours; this position includes some evening and weekend work.
Ideal candidates will have a degree in biology, marine biology, psychology, chemistry, or biochemistry. We will also consider candidates with other majors if interested in biology and science, or without degrees.
You must be:
- Willing to handle animals
- Responsible and detail-oriented
- A flexible, self-motivated team player
- Ready to learn and work hard at doing good science for our customers
Pay is very competitive, based on experience. Hooke offers health insurance, 401(k), company contributions to HSAs, and paid vacation.
To apply:
- Email to (no calls, please)
- Attach your resume or CV in PDF format
- Put "ENTRY LEVEL SCIENTIST - [last name], [major], GPA [gpa]" in the subject line
Other positions
Please send your resume or CV via email to . Please include your GPA.
Hooke Laboratories is an Equal Opportunity Employer.

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